Multiple myeloma (MM) is a malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure.

MM is most frequently diagnosed among people aged 65 to 74 years.

Smoldering (asymptomatic) myeloma describes a stage of disease with no symptoms and no related organ or tissue impairment. Patients with asymptomatic smoldering MM may have an indolent course for many years without therapy.

The majority of patients with symptomatic or active MM have bone disease, and a third have renal compromise. Other complications such as infections, hypercalcemia, hyperviscosity, and coagulation/thrombosis may occur.